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KMID : 0356620070220020135
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Journal of Korean Society of Endocrinology
2007 Volume.22 No. 2 p.135 ~ p.141
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Two Cases of Acromegaly with Empty Sella Syndrome Treated by Long-Acting Release Octreotide
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Kim Dong-Jin
Baik Sei-Hyun
Kim Sin-Gon
Seo Ji-A
Kim Nan-Hee
Choi Kyung-Mook
Choi Dong-Seop
Yang Sae-Jeong
Seo Young-Jin
Eun Chai-Ryoung
Chung Hye-Soo
Choi Hey-Jung
Kim Hye-Sook
Park Ju-Ri
Yoo Hye-Jin
Park Soo-Yeon
Lee Yun-Jeong
Ryu Ohk-Hyun
Kim Hee-Young
Lee Kye-Won
Kim Nam-Hoon
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Abstract
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Two cases of typical acromegaly with empty sella syndrome presented to our institution. In the natural course of untreated pituitary adenoma, empty sella syndrome may result from necrosis by infarction or from hemorrhage of the pituitary gland. In our patients, the secretion of growth hormone continued in spite of the existence of empty sella syndrome. In one case, we confirmed the hypersecretion of growth hormone from sella by jugular vein sampling. Medical therapy with somatostatin analogue was attempted because there was no obvious mass in the sella. After 6~12 months of treatment with long-acting release octreotide, clinical features in our patients were improved, and the level of growth hormone and IGF-1 were also normalized.
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KEYWORD
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Acromegaly, Empty sella syndrome, Octreotide
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